The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.

Monday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Indianapolis Colts NFL Week 16 game Dec. 22, 2025.

The Tennessee Titans are searching for their next head coach, and Indianapolis Colts defensive coordinator Lou Anarumo could be a fit.

A pair of Offensive Player of the Year candidates face off on Monday Night Football in Week 16, as Christian McCaffrey and the San Francisco 49ers hit the road

The Colts (8-4) have lost four straight games and are in the midst of a free-fall down the AFC standings after an excellent start. They went from being one of the early bright spots of the season and a potential redemption story to one of the unfortunate victims of poor injury luck when quarterback Daniel Jones went down with a torn Achilles.

The San Francisco 49ers are taking on the Indianapolis Colts at 5:15 p.m. PDT on Dec. 22 at Lucas Oil Stadium on Monday Night Football.

Catch the 49ers take on the Colts on Monday, December 22. Here's everything you need to know to stream the Monday Night Football game.

JJ Stankevitz from the Indianapolis Colts previews Week 16 "Monday Night Football", with one-on-one interviews featuring San Francisco 49ers DL Clelin Ferrell and WR Jauan Jennings.

The Saints and Titans have been playing some good football lately, which should make for a fascinating matchup in Nashville on Sunday. The Saints just won their third straight game with a comfortable 23-point win over the New York Jets in The Big Easy.