In this paper, [4] the authors studied a community-based cohort of patients with a diagnosis of diabetes mellitus and a postdiagnosis serum creatinine measurement who were receiving care in the ...

COOH) represents the protonated form of the organic acid, whereas lactate (CH₃CH (OH)COO⁻) represents its conjugated base.

A 58-year-old woman who has adult-onset diabetes mellitus, hypertension, and hyperlipidemia was taking simvastatin (Zocor) 40 mg, glyburide (Diabeta) 20 mg, metformin (Glucophage) 850 mg t.i.d., ...

How high can creatinine go before you must stop or alter the metformin dose? —MICHAEL QUIRK, PA-C, Cudjoe Key, Fla. A principal concern in patients using metformin is the development of lactic ...

Metformin-associated lactic acidosis (MALA) is a rare but serious adverse effect of the diabetes drug metformin in which the body accumulates too much lactic acid. Investigators developed and tested a ...

During a recent shift, our emergency department (ED) team saw a patient with fairly severe diabetic ketoacidosis. The patient's serum bicarbonate level was 6 mEq/L and the venous pH was 6.85. During ...