A protein's function is determined by its structure, and structure—the way a protein folds—is determined by its sequence of ...

Proteins are the end products of the decoding process that starts with the information in cellular DNA. As workhorses of the cell, proteins compose structural and motor elements in the cell, and they ...

Efforts to unlock the mysteries of proteins, building blocks of life, have earned three scientists the 2024 Nobel Prize in chemistry. The prize goes to David Baker “for computational protein design,” ...

Astronomers use the term dark energy to refer to energy in the universe that is unaccounted for by ordinary matter but necessary to explain cosmology. Astronomy, however, isn't the only field with ...

This Brush Up is sponsored by Quanterix. Learn more about tau biomarkers and clinical applications. Tau is a flexible protein that stabilizes the internal structure of neurons and supports ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...

In genetics, one harmful variant can be enough to cause disease—but two can make it far more severe. One notable example is KJ, an infant diagnosed with a rare urea cycle disorder with a grim ...

A grayscale ribbon representation of a protein with space filling representations of a steroid (orange) and β-lactamase active site (green). One of the hormone-binding protein switches Credit: Kirill ...

Protein is having a cultural moment, and nearly all the advice points one way: get more. Far less is said about the other ...

This important study identifies and characterizes a set of amino acid states that can rescue protein function in the presence of substantially deleterious mutations. Some of these super-compensatory ...