Proteins are made of chains of amino acids, and a basic tenet of biology is that the sequence of amino acids determines how a protein folds into a 3D shape which, in turn, dictates the protein’s ...

Scientists at the VIB–VUB Center for Structural Biology have uncovered a counterintuitive principle that could reshape how ...

Protein design aims to create customized antibodies for therapies, biosensors for diagnostics, or enzymes for chemical reactions. An international research team has now developed a method for ...

A team of researchers at the Korea Advanced Institute of Science and Technology (KAIST) has used artificial intelligence to ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

An interdisciplinary research team from Leipzig University and the Saxon AI center ScaDS.AI has developed a novel approach that integrates artificial intelligence (AI) methods with biophysical ...

Recent advances in de novo protein design are transforming biology into an increasingly generative discipline. Fueled by progress in machine learning, we can now generate novel proteins in silico with ...

A multicolored 3D model of an enzyme binding double-stranded DNA against a light purple background Computational enzyme design could allow for reactions not seen in nature. Credit: Ian Haydon ...

Researchers developed AI tools that designed drug molecules while accounting for protein movement during binding. The tools ...

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...