Scientists have visualized for the first time how opioids such as loperamide and the antidote naloxone engage a key brain ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

An in-depth review of chronic postfracture pain, detailing prevalence, modifiable risk factors (smoking, obesity), neural/molecular mechanisms, and assessment tools to support non-opioid analgesic ...

The findings of this study confirm that negative reinforcement is a core mechanism in opioid addiction, which is well established in preclinical research but less represented in treatment. Importantly ...

There are three obstacles to faster development and deployment of non-addictive pain treatments. They are the business ...

Using powerful 7-Tesla brain imaging, researchers mapped how the brainstem manages pain differently across the body. They ...

Over-the-counter pain medications work as well or better than opioids after wisdom tooth extraction for both men and women, ...