A paper published in Nature Communications shows that when neurons are given information about the changing world around them (task-related sensory input) it changes how they behave, putting them on ...

Loss- and gain-of-function variants in the gene encoding KCNQ2 channels are a common cause of developmental and epileptic encephalopathy, a condition characterized by seizures, developmental delays, ...

Researchers modeled long-term iron accumulation in neurons and identified chronoferroptosis. Chronic exposure reduced ...

The findings, published in Nature on July 19, shed light on potential neural mechanisms involved in working memory and decision making. "Our study is a step toward thinking of the brain not in terms ...

Excitation/inhibition balance is crucial to homeostatic brain function and disrupted in several neurodevelopmental and neurodegenerative diseases. Cortical inhibitory neurons derived from the medial ...

An EEG (electroencephalogram) is a painless test that uses small sensors placed on the scalp to measure the brain’s electrical activity. It provides a real-time readout of brain “waves”—rhythms ...

The use of iPSC-derived neurons to model human diseases like Alzheimer’s has enabled new advances. Nonetheless, a limitation of these cells is that their reprogramming resets epigenetic marks, erasing ...

Researchers have used microRNA-based direct reprogramming to generate neurons from fibroblasts, providing new insights into late-onset Alzheimer’s disease. Aging is the most significant risk factor ...

The spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer’s disease and frontotemporal dementia—has been studied with a model that incorporates human ...

Zebrafish, photographed with confocal microscope. The brain region that controls eye movement is structurally similar in fish and mammals, but the zebrafish system contains only 500 neurons, making it ...