Recently, a research group from Hefei Institutes of Physical Science (HFIPS) of Chinese Academy of Sciences (CAS) and The Second Hospital of Anhui Medical University dissected, for the first time, the ...
Conclusion Population-level identification of patients with MMR mutation-positive endometrial cancer is optimized by stepwise testing for tumor MMR IHC loss in patients younger than 60 years, tumor ...
Lynch syndrome (MIM #120435) is a heritable condition associated with increased risk of different forms of cancer [1]. It results from a germline inactivating variant causing loss of function of one ...
After learning that I had Lynch syndrome and a MLH1 mutation, I changed my lifestyle to hopefully prevent a cancer diagnosis. After meeting with a genetic counselor, undergoing genetic testing for ...
Genotype-informed surveillance should pair colonoscopy with upper endoscopy when MLH1/MSH2 mutations or family history elevate gastric cancer risk. Finding benign polyps during routine scopes ...
This initiative was led by Alexander C. Mackinnon, M.D., Ph.D., Robert B. Adams Endowed Professor, Executive Vice Chair, Division Director, Genomic Diagnostics and ...
Clinicopathologic data from a population-based endometrial cancer cohort, unselected for age or family history, were analyzed to determine the optimal scheme for identification of patients with ...
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