In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

Scheme showing the structure of cytosine, 5-methylcytosine, and 5-hydroxymethylcytosine. Adding a methyl group to the DNA base cytosine represses gene expression in mammalian cells. To remove the ...

In 1995, with the Human Genome Project underway, sequencing was all the rage. Scientists working on the project cloned short fragments of the whole genome and used Sanger sequencing to determine the ...

Haoyu Cheng, PhD, assistant professor of biomedical informatics and data science at Yale School of Medicine, has developed a new algorithm capable of building complete human genomes using standard ...