Computational chemists at the University of Amsterdam's Van 't Hoff Institute for Molecular Sciences have developed a ...

This image depicts the chemical structure of cytosine. It shows a hexagonal ring with nitrogen atoms at positions 1 and 3, and a primary amine group attached to carbon 4. The two remaining positions ...

Understanding the mechanisms of protein-DNA binding is critical in comprehending gene regulation. Three-dimensional DNA structure, also described as DNA shape, plays a key role in these mechanisms. In ...

DNA repair systems have evolved to rectify exogenous or endogenous DNA lesions. FAN1 (FANCD2/FANCI associated nuclease 1) 1,2,3,4,5 is a DNA repair enzyme involved in removal of extrahelical ...

Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process.

DNA aptamers are powerful molecular tools in biosensing, bioimaging and therapeutics. However, a limited understanding of their tertiary structures and binding mechanisms hinders their further ...

Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...