The two strands of DNA, although chemically equivalent, are replicated and repaired asymmetrically. Insights into the persistence of DNA damage show how strand-specific interactions shape the ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...

我们通常把DNA复制(DNA replication)理解成一个高度准确的“复制”过程：一条染色体复制成两条DNA序列几乎完全相同的姐妹染色单体(sister chromatids)，随后它们彼此黏连，等待细胞分裂时被准确分配。

As DNA strands ravel and unravel in an intricate dance, one notable event takes center stage: replication. This process is essential to life, but the finer details of its orchestrated steps are still ...

Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists have analyzed the molecular evolution of tumors after exposure to mutagenic chemicals.